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Correcting Nutrient Deficiencies Essential for Brain Health: NHANES Analysis

New research breaks down how boosting select nutrients may help to maintain long-term cognitive performance.

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By: Mike Montemarano

Associate Editor, Nutraceuticals World

A new analysis of data from the National Health and Nutrition Examination Survey (NHANES) found that elevated intake of several nutrients was associated with higher cognitive elasticity in people over the age of 65.

The analysis, conducted by Pharmavite, LLC, expressed the need for supplementation as  these vitamins are taken at sub-optimal levels in U.S. adults.

The cross-sectional study included participants 60 years and older with validated cognitive function data (cognitive function test or CFT) or valid depression score data (Patient Health Questionnaire or PHQ). The researchers examined their nutrient intake to discern associations with cognitive function and depression.

The key nutrients with the most consistent associations with cognitive function were vitamins K, A, and B6, folate, lutein, zeaxanthin, and several minerals.

Optimal intakes of vitamin K and folate are particularly difficult to achieve through diet alone, according to Gnosis by Lesaffre, a supplier partner of Pharmavite. Emerging evidence has revealed that vitamin K2 supports a healthy vascular structure within the brain, and further supports cognition through anti-inflammatory and antioxidant actions.

Folate deficiency has been linked to accelerated cognitive function decline and might serve as a marker for assessing cognitive health in older individuals. According to Gnosis, research has associated low serum folate levels with significantly increased risk of severe cognitive decline in adults over the age of 65.

“Current research has illuminated the potential necessity for a personalized approach to combatting cognitive decline associated with aging, emphasizing the pivotal role of nutrients in sustaining a healthy brain,” says Jean-François Jeanne, substantiation and applications manager at Gnosis by Lesaffre, supply partner of Pharmavite. “Pharmavite’s analysis illuminates how nutrient intake can impact cognitive abilities, especially Vitamin K2 and Folate, providing a powerful incentive to enhance multivitamins and other nutritional products with scientifically proven amounts of K2 and Folate, such as MenaQ7 and Quatrefolic.”

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